Laparoscopy is the technique of using the "pneumoperitoneum" process to 

extend and examine the abdominal cavity using CO2. Laparoscopic and other 

procedures produce pain, which varies in intensity, duration, and type. 

Crystalloid fluid types, for instance, Normal saline (NS) and Ringer's lactate 

(RL) solution, aid in reducing laparoscopic pain. Therefore, the research 

explores intraperitoneal crystalloid solutions in reducing post-laparoscopic 

surgery shoulder pain. The research adopted a prospective, single-blind study 

based on a single-center, randomized, and parallel research design. A total of 

80 diagnosed patients (40 subjects in each arm) with laparoscopic surgery 

were randomly recruited at Zintan Medical Center, Alzintan, Libya. Patients 

were equally divided into Group A (crystalloid solutions) and Group B (routine 

measures) and were assessed through self-administered pain scores. 

Through the numeric rating scale (NRS), the research findings revealed 

significant pain intensity differences between Groups A and B at 6, 12, 24, 

48, and 72 hours. In contrast, no significant difference in pain was observed 

between groups A and B on the fourth and fifth days. Additionally, lower pain 

intensity was observed in group A than in group B; at 6 hours, the mean pain 

score for group A and B measured 2.55 and 6.40 at 6 hours, respectively. The 

intraperitoneal crystalloid solutions infusion aids in reducing pain severity 

among laparoscopic surgery patients. Future research should address 

extended follow-up periods to determine the effects of NS and RL 

interventions. Moreover, stakeholders should implement Ringer's lactate 

solution (RL) to reduce post-laparoscopic complications

This study evaluates a sustainable preplaced aggregate (two-stage) fiber-reinforced concrete (PAFRC) that incorporates Portland limestone cement (PLC) and high dosages of polypropylene (PP) and alkali-resistant glass (GF) fibers. Aggregates and fibers were preplaced in the formwork and subsequently injected with a flowable grout; mechanical performance was assessed at 28 days. The results indicate that 4% PP increased compressive strength, splitting-tensile strength, and elastic modulus by 15.2%, 15.9%, and 18.6%, respectively, whereas 1% and 2% GF improved flexural strength by 10.2% and 10.4%, respectively. The 2% PP mixture exhibited the highest compressive strength (20.3 MPa), and the 4% PP mix attained the greatest splitting-tensile strength (3.6 MPa). Peak flexural performance (4.9 MPa) was observed for both the 6% PP and 2% GF mixes. Incorporating PLC in the PAFRC system reduces clinker demand and embodied CO2, and the preplaced method enables higher fiber contents without severe segregation. These results demonstrate a practical pathway to enhance both the mechanical performance and sustainability of concrete for repair and structural applications.

Abstract

This work presents advanced methodologies for the improvement of the Jacobi method by incorporating Gauss-Seidel iterative schemes [1][2]. The Jacobi method, though simple to use [3][4], usually suffers from slow convergence, especially for large-scale linear systems [5]. In this regard, a hybrid scheme is presented that utilizes the strengths of both the Jacobi and Gauss-Seidel methods [6][7]. The important techniques that form the basis of this study include successive over-relaxation (SOR) to accelerate the convergence [2][8], adaptive step-sizing based on residual monitoring [9][10], and preconditioning techniques that enhance the numerical properties of the linear systems [11][12]. Furthermore, the effect of reordering equations for improved convergence rates is also considered [11]. Numerical experiments performed in the context of this study show that these enhancements significantly reduce the number of iterations required for acceptable solutions, thus enhancing computational efficiency [2][13]. In this context, the proposed hybrid scheme outperforms the traditional Jacobi and Gauss-Seidel methods for several scenarios and provides a robust solution for practitioners working in applied mathematics and engineering disciplines [2]. Keywords: Jacobi Method, Gauss-Seidel Method, Iterative Methods, Linear Systems, Convergence Analysis, Successive Over, Relaxation (SOR), Preconditioning.

bstract:

There is an increasing link between oxidative stress, inflammation, and neuronal damage in 

neurodegenerative dis-eases. Therefore, there is the need for safer natural neuroprotective drugs 

to protect neurons from damage. This study aimed to investigate the neuroprotective effect of 

natural extracts derived from Olea Europaea plants from Libya. Leaves and fruits of the olives 

were extracted using ethanol and methanol solvents. The extracts were then analyzed for the 

presence of phytochemicals and antioxidants, and neuroprotective activity was determined 

using neuronal cell models. Findings from the study show that olive extract was rich in phenols, 

flavonoids, oleuropein, and hydroxytryrosol in methanol extracts of leaves. There was a high 

free radical scavengeing capacity as shown by antioxidant activity tests. Moreover, 

neuroprotective studies show that the extracts could in-crease neuronal cell viability and reduce 

intracellular reactive oxygen species when cells are exposed to oxidative stress. Inflammation 

markers such as TNF-α and IL-6 were also inhibited by the extracts.

Keywords: Olea Europaea, Neuroprotection, Antioxidant Activity, Olive Extracts, 

Neurodegenerative Diseases.

 الملخص: 

يتزايد االرتباط بين اإلجهاد التأكسدي وااللتهاب وتلف الخاليا العصبية في األمراض التنكسية العصبية. لذا، تبرز الحاجة إلى 

أدوية طبيعية أكثر أمانًا لحماية الخاليا العصبية من التلف. هدفت هذه الدراسة إلى بحث التأثير الوقائي العصبي لمستخلصات

( من ليبيا. تم استخالص أوراق وثمار الزيتون باستخدام Olea Europaea الزيتون األوروبي ) طبيعية مشتقة من نباتات 

مذيبات اإليثانول والميثانول. ثم تم تحليل المستخلصات للكشف عن وجود المركبات الكيميائية النباتية ومضادات األكسدة، 

ص الزيتون غني وتم تحديد النشاط الوقائي العصبي باستخدام نماذج الخاليا العصبية. أظهرت نتائج الدراسة أن مستخل

بالفينوالت والفالفونويدات واألولوروبين والهيدروكسي تيروسول في مستخلصات الميثانول من األوراق. كما أظهرت 

اختبارات النشاط المضاد لألكسدة قدرة عالية على التخلص من الجذور الحرة. عالوة على ذلك، تُشير الدراسات الوقائية

ة على زيادة حيوية الخاليا العصبية وتقليل أنواع األكسجين التفاعلية داخل الخاليا عند العصبية إلى أن المستخلصات قادر

بواسطة المستخلصات IL-6 و TNF-α تعرضها لإلجهاد التأكسدي. كما تم تثبيط عالمات االلتهاب مثل 

لحماية العصبية، نشاط مضاد لألكسدة، مستخلصات الزيتون، األمراض التنكسية ا، Olea Europaea الكلمات المفتاحية:

. العصبية

This study reports the development of a new series of pyrazolo[4,3-b] pyridine and pyrazolo[1,5-a] pyrimidine derivatives designed as potential antischistosomal agents. A diverse set of fused nitrogen-containing heterocycles was successfully obtained and subjected to preliminary biological relevance assessment based on their structural features. These newly synthesized frameworks, belonging to scaffolds previously associated with notable antimicrobial and antiparasitic properties, demonstrate promising potential for further evaluation against Schistosoma species. The findings highlight the value of these heterocyclic systems as candidates for developing alternative therapies to complement existing schistosomiasis treatment strategies

Keywords: Pyrazolopyridines; Pyrazolopyrimidines; Heterocyclic synthesis; Condensation reactions

(E)-2-(naphthalen-1-yldiazenyl) malononitrile (NDMN) was synthesized via a diazotization–coupling reaction and evaluated for its antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. The compound showed strong, concentration-dependent antibacterial activity, with significantly higher efficacy against MRSA than E. coli, as confirmed by disc diffusion, MIC, and MBC assays. These results suggest that NDMN is a promising synthetic antimicrobial agent, particularly against Gram-positive resistant bacteria, and merits further biological and toxicity investigations.

The rise of multidrug-resistant (MDR) bacteria poses a significant challenge to the antibacterial efficacy of the

produced chemical, (2-(2-(2-nitrophenyl) diazinyl) malononitrile), which is generated from malononitrile and a

diazo moiety. The molecule was synthesized using the diazotization of 2-nitroaniline, followed by coupling with

malononitrile, resulting in NPDAM with an 85% yield and a melting point of 123-125 °C. The substance at

concentrations of 1, 5, and 10 mg/mL was assessed against methicillin-resistant Staphylococcus aureus (MRSA)

(SA121) and Escherichia coli (EC49). The chemical exhibited efficacy against MRSA at varying doses, yielding

clear zones of 29.6, 32.6, and 33.0 mm, in contrast to E. coli at the same concentrations, which produced clear

zones of 10, 11.6, and 14.6 mm, respectively. The microdilution technique was employed to ascertain the

minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The compound

exhibited low minimum inhibitory concentration (MIC) values against MRSA at concentrations of 1 and 5 mg/mL

(19.5 and 4.89 μg/mL, respectively), in contrast to E. coli, which demonstrated inhibition at 39.0 and 9.78 μg/mL

at the same concentrations. Additionally, it yielded the lowest MIC values (0.97 μg/mL) against both bacteria at

a concentration of 10 mg/mL. The MBC values against MRSA ranged from 39.0 to 1.95 μg/mL, while against

E. coli, the MBC values were slightly lower, ranging from 78.1 to 1.95 μg/mL. In conclusion, all chemical

concentrations exhibited activity against the studied microorganisms, indicating their potential as antimicrobial

agents.

Keywords: Malononitrile, Diazo compounds, antimicrobial activity, MRSA, E. coli.