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المنشورات العلمية

الرئيسية // المنشورات العلمية
Dynamic oxygen-enhanced MRI of cerebrospinal fluid
Journal Article

Oxygen causes an increase in the longitudinal relaxation rate of tissues through its T1-shortening effect owing to its paramagnetic properties. Due to such effects, MRI has been used to study oxygen-related signal intensity changes in various body parts including cerebrospinal fluid (CSF) space. Oxygen enhancement of CSF has been mainly studied using MRI sequences with relatively longer time resolution such as FLAIR, and T1 value calculation. In this study, fifteen healthy volunteers were scanned using fast advanced spin echo MRI sequence with and without inversion recovery pulse in order to dynamically track oxygen enhancement of CSF. We also focused on the differences of oxygen enhancement at sulcal and ventricular CSF. Our results revealed that CSF signal after administration of oxygen shows rapid signal increase in both sulcal CSF and ventricular CSF on both sequences, with statistically significant predominant increase in sulcal CSF compared with ventricular CSF. CSF is traditionally thought to mainly form from the choroid plexus in the ventricles and is absorbed at the arachnoid villi, however, it is also believed that cerebral arterioles contribute to the production and absorption of CSF, and controversy remains in terms of the precise mechanism. Our results demonstrated rapid oxygen enhancement in sulcal CSF, which may suggest inhaled oxygen may diffuse into sulcal CSF space rapidly probably due to the abundance of pial arterioles on the brain sulci.


Taha M Mehemed, (06-2014), PLoS One: Public Library of Science, 9

Visualization of Lenticulostriate Arteries at 3T: Optimization of Slice-selective Off-resonance Sinc Pulse–prepared TOF-MRA and Its Comparison with Flow-sensitive Black-blood MRA
Journal Article

Rationale and Objectives

To optimize visualization of lenticulostriate artery (LSA) by time-of-flight (TOF) magnetic resonance angiography (MRA) with slice-selective off-resonance sinc (SORS) saturation transfer contrast pulses and to compare capability of optimal TOF-MRA and flow-sensitive black-blood (FSBB) MRA to visualize the LSA at 3T.

Materials and Methods

This study was approved by the local ethics committee, and written informed consent was obtained from all the subjects. TOF-MRA was optimized in 20 subjects by comparing SORS pulses of different flip angles: 0, 400°, and 750°. Numbers of LSAs were counted. The optimal TOF-MRA was compared to FSBB-MRA in 21 subjects. Images were evaluated by the numbers and length of visualized LSAs.

Results

LSAs were significantly more visualized in TOF-MRA with SORS pulses of 400° than others (P < .003). When the optimal TOF-MRA was compared to FSBB-MRA, the visualization of LSA using FSBB (mean branch numbers 11.1, 95% confidence interval (CI) 10.0–12.1; mean total length 236 mm, 95% CI 210–263 mm) was significantly better than using TOF (4.7, 95% CI 4.1–5.3; 78 mm, 95% CI 67–89 mm) for both numbers and length of the LSA (P < .0001).

Conclusions

LSA visualization was best with 400° SORS pulses for TOF-MRA but FSBB-MRA was better than TOF-MRA, which indicates its clinical potential to investigate the LSA on a 3T magnetic resonance imaging.

TAHA M Mehemed, (06-2014), Academic Radiology: Elsevier, 21

Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart
Journal Article

Mercury exposure is associated with increased risk of cardiovascular disease and profound cardiotoxicity. However, the correlation between Hg(2+)-mediated toxicity and alteration in cardiac cytochrome P450s (Cyp) and their dependent arachidonic acid metabolites has never been investigated. Therefore, we investigated the effect of acute mercury toxicity on the expression of Cyp-epoxygenases and Cyp-ω-hydroxylases and their associated arachidonic acid metabolites in mice hearts. In addition, we examined the expression and activity of soluble epoxide hydrolase (sEH) as a key player in arachidonic acid metabolism pathway. Mercury toxicity was induced by a single intraperitoneal injection (IP) of 2.5 mg/kg of mercuric chloride (HgCl₂). Our results showed that mercury treatment caused a significant induction of the cardiac hypertrophy markers, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP); in addition to Cyp1a1, Cyp1b1, Cyp2b9, Cyp2b10, Cyp2b19, Cyp2c29, Cyp2c38, Cyp4a10, Cyp4a12, Cyp4a14, Cyp4f13, Cyp4f15, Cyp4f16 and Cyp4f18 gene expression. Moreover, Hg(2+) significantly increased sEH protein expression and activity levels in hearts of mercury-treated mice, with a consequent decrease in 14,15-, and 11,12-epoxyeicosatrienoic acids (EETs) levels. Whereas the formation of 14,15-, 11,12-, 8,9-dihydroxyeicosatrienoic acids (DHETs) was significantly increased. In conclusion, acute Hg(2+) toxicity modulates the expression of several Cyp and sEH enzymes with a consequent decrease in the cardioprotective EETs which could represent a novel mechanism by which mercury causes progressive cardiotoxicity. Furthermore, inhibiting sEH might represent a novel therapeutic approach to prevent Hg(2+)-induced hypertrophy.

Issa Emhemmed Alemyani Amara, (04-2014), Toxicology Letters: Elsevier, 219

Electrical conductivity and dielectric relaxation of 2-(antipyrin-4-ylhydrazono)-2-(4-nitrophenyl)acetonitrile
Journal Article

The electrical and dielectric properties of the synthesized 2-(antipyrin-4-ylhydrazono)-2-(4-nitrophenyl)acetonitrile (AHNA) have been studied. The direct and alternating current (DC and AC) conductivities and complex dielectric constant were investigated in temperature range 303–403 K. The AC conductivity and dielectric properties of AHNA were investigated over frequency range 100 Hz–5 MHz. From DC and AC measurements, electrical conduction is found to be a thermally activated process. The frequency-dependent AC conductivity obeys Jonscher's universal power law in which the frequency exponent decreases with increasing temperature. The correlated barrier hopping (CBH) is the predominant model for describing the charge carrier transport in which the electrical parameters are evaluated. The activation energy is found to decrease with increasing frequency. The behaviors of dielectric and dielectric loss are discussed in terms of a polarization mechanism. The dielectric loss shows frequency power law from which the maximum barrier height is determined as 0.19 eV in terms of the Guintini model.

Hagar Hussien Hussien Nawar, (03-2014), Physica B: Condensed Matter: North-Holland, 437

NEW AND ONE POT-SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIDINES FROM ENAMINOKETONES
Journal Article

Several new pyridine derivatives were prepared via reacting the enaminoketones 1a-d with active hydrogen reagents. Reaction of the enaminoketones 1a-c with 4-acetyl-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one 2a yielded the pyridines 3a-c. Condensation of the enaminonitrile 1d with 2b-d or 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3- dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile 8 give the pyridine derivatives 6a-c and 10 respectivly. Also, (E)-3- (3-(dimethylamino)acryloyl)-2H-chromen-2-one 1a reacted with active methylenes in diethyl 3-oxopentanedioate 12 and 4-methyl-6-oxo-2-thioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile 15 to afford the pyridine derivatives 14 and 16 respectively.

Hagar Hussien Hussien Nawar, (03-2014), GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES: gjesr, 1

تاريخ المغرب وحضارته `دراسة للجيش والاسطول والمنشآت في الدولة المرينية 668 - 869 هــ / 1269 - 1465م`
كتاب

يهدف إلى إبراز الجانب الحضاري للمغرب الإسلامي وخاصة في مجال الحرب، حيث تم التركيز فيه على نظم الحرب للدولة المرينية، والتي تمثلت في ثلاثة موضوعات رئيسة وهي: الجيش والأسطول والمنشآت. يبرز المعلومات المهمة عن نظم الجيش في عناصر تناولت الجند، واللباس، والأسلحة، والقواعد الحربية، وكذلك تفاصيل عن الأسطول ونظمه سواء كانت تخص السفن والأسلحة والقواعد ودور الصناعة، ويتناول أيضاً المنشآت المرينية من مدن وقلاع وحصون، والتي بدورها ستفصح له عما تحتويه من استحكامات من أسوار، وأبراج، ومداخل. ويعد هذا العمل انعكاسا صادقا وأمينا يلبي حاجة المتخصصين في التاريخ الإسلامي عامة، والمغرب والأندلس خاصة. 

سالم ابو القاسم محمد غومة، (01-2014)، القاهرة: دار الفكر العربي،

Botryodiplodia sp. canker on Ficus benjamina in Egypt.
Journal Article

Abstract- Botryodiplodia sp. AUMC 9468 was isolated in pure culture from canker on Ficus benjamina, on side of Ibraheemia bank stream at Assiut governorate, Egypt. The analysis of growth condition suggested the trees were stressed induced by light, nutrient and medium factors. This report is the first for Botryodiplodia canker on F. benjamina in Egypt. The pathogenicity test were resulted on that the fungus was introduced with the trees, penetrated through bark wounds, and incubated under conditions stressful to the well-being of the tree.

Keywords- Canker,Ficus benjamina, Botryodiplodia.


Mohamed Ahamed Al-Ryani, (12-2013), World Research.: Journal of Agricultural Biotechnology, 1

Digital intellectual property as a service (DIPaaS): For mobile cloud users
Journal Article

With the integration of cloud computing, smart phones enormously improved in processing power, storage, communication efficiency, and reliability. The technical architecture of Cloud strongly supports the efficient delivery of services in mobile environment. Whereas the mobile cloud users can access all the resources as a service dynamically in elastic mode. Accessing Digital Intellectual Property as a Service (DIPaaS) on flexible economic basis is a major interest among the mobile users. DIP is the piece of work of human intellectual in digital form such as eBook, software program, e-painting, movie, song, computer game, and etc. The DIP services complex in nature, involves creator, manufacturer, distributor, licensing agencies, and service providers. However, the service limitations exist, shall be overcome with an understanding approach to Service Level Agreement (SLA). DIP applications consume a large of local resources and could not be implemented on standalone mobile phones. Therefore, we realize increasing demand for an efficient service-model which satisfies the mobile cloud users at large. We proposed the first service-model includes both technical and service architecture to encourage the stakeholders for DIP access in mobile cloud environment. Eventually we present an efficient access to Digital Intellectual Property as a Service in Mobile Cloud Environment (DIPaaSMCE).


GUMA Abdulkhader Muntaser Lakshen, Khalid Mohiuddin, (11-2013), International Symposium on Computational and Business Intelligence (ISCBI): IEEE International Conference on Antennas, 1

الرّتبة في الجملة العربيّة
مقال في مجلة علمية

يتناول هذا البحث الموسوم بـ:" الرّتبة في الجملة العربيّة" جماليّات الرّتبة ــ التّقديم والتّأخيرــ وهي من أساسيّات النّحو العربيّ؛ إذ تحصل العلاقات النّحويّة بين الكلمات من خلال انتظامها في ترتيب معيّن في الجملة العربيّة ، فمن المعروف أنّ لكلّ عنصر في الجملة العربيّة ترتيبا خاصّا يتعيّن به شأنه ، إذ تنتظم العناصر في نظام مألوف قائم على النّظام النّحويّ ، واهتمام الّنحاة والبلاغيّين بموضوع الرّتبة يأتي من أثرها على المعنى وتأثيرها في السّامع ــ وهو هدف اللّغة ــ

               وبناء على ذلك لابدّ من معرفة حالات الرّتبة ؛ لأنّها تعدّ متغيّرا أسلوبيّا في اللّغة لا يرد اعتباطا في نظم الكلام ، وإنّما هو عمل مقصود تقتضيه دواع عدّة، منها: النّحويّ ، ومنها: البلاغيّ.

               واقتضت طبيعة البحث أن يكون تقسيمه على مبحثين، الأوّل : يتناول تعريف الرّتبة لغة واصطلاحا، والحاجة الّتي دعت لها، وترتيب الألفاظ داخل التّركيب وفقا لترتّب معانيها، أمّا الثّاني: فيتناول الرّتبة بين النّحو والبلاغة بشيء من التّفصيل والتّمثيل ؛ ليأخذ الموضوع صورته المتكاملة.

               ومن أهمّ النّتائج الّتي توصّل إليها البحث:

1ــ هدف اللّغة هو " الإيصال والإفهام" لذلك نرى أنّ للمعنى منزلة مهمّة في ترتيب الكلمات داخل الجملة.

2ــ المتكلّم لا يقدّم أو يؤخّر إلّا بقصد إفادة معنى معيّن لا يتأتّى إلّا بما قدّم أو أخّر.

3ــ مصطلح الرّتبة أعمّ و أشمل من مصطلح التّقديم والتّأخير.

4ــ الإعراب أعطى مرونة للجملة العربيّة ؛ وذلك بما تكفّل به من إيضاح للمعنى، ممّا سمح للكلمات بحرّيّة الانتقال من موضع إلى آخر داخل التّركيب؛ لأغراض بلاغيّة دون حدوث لبس.

5ــ كانت مرتبة اللّفظ والتّركيب أعلى من مرتبة المعنى عند النّحويّين ، أمّا عند البلاغيّين فقد كان المعنى هو الرّكيزة الأساسيّة في دراسة التّركيب.   



حفصة الطاهر المبروك سالم، (09-2013)، جامعة طرابلس: مجلّة التّبيان، 6

Fat-water interface on susceptibility-weighted imaging and gradient-echo imaging: comparison of phantoms to intracranial lipomas
Journal Article

OBJECTIVE. In a clinical setting, lipoma can sometime show low signal intensity on susceptibility-weighted imaging (SWI) mimicking hemorrhage. The purpose of this study was to evaluate the fat-water interface chemical-shift artifacts between SWI and T2*-weighted imaging with a phantom study and evaluate SWI in lipoma cases.

MATERIALS AND METHODS. SWI, magnitude, high-pass filtered phase, and T2*-weighted imaging of a lard-water phantom were evaluated in the in-phase, out-of phase, and standard partially out-of-phase TE settings used for clinical 3-T SWI (19.7, 20.9, and 20.0 ms, respectively) to identify the most prominent fat-water interface low signal. SWI of five cases of CNS lipoma were retrospectively evaluated by two neuroradiologists.

RESULTS. TE at 19.7 ms (in-phase) showed the minimum fat-water interface low signal in the phase-encoding direction on magnitude, high-pass filtered phase, and SWI. TE at 20.9 ms (out-of-phase) showed the maximum fat-water interface in the phase-encoding direction on magnitude, high-pass filtered phase, and SWI. TE at 20.0 ms (partially out-of-phase) showed more fat-water interface low signal on SWI than on T2*-weighted imaging, especially in the phase-encoding direction. All lipomas in the five patients showed high signal intensity with surrounding peripheral dark rim on SWI.

CONCLUSION. Fat-water interface is more prominent on the standard TE setting used for clinical SWI (20.0 ms) than that of T2*-weighted imaging and shows a characteristic surrounding peripheral low-signal-intensity rim in lipoma. Knowing the fat-water appearance on SWI is important to avoid misinterpreting intracranial lipomas as hemorrhages.

TAHA M. Mehemed, (09-2013), American Journal of Roentgenology: American Roentgen Ray Society, 210