Environmental factors are known to influence carcinogenesis. Procarcinogens, such as heterocyclic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs), are examples of these environmental factors. Procarcinogens are chemically inert and require bioactivation, via enzymes such as Cytochrome P450 (CYP). CYP1A1 isoform, regulated by Aryl hydrocarbon receptor (AhR), plays a significant role in the bioactivation of PAHs and HAs. AhR has multiple co-activators and co-repressors, of which SMRT (silencing mediator for retinoid and thyroid hormone receptors) has been identified as a major co-repressor for AhR. In the present study we examined the effect of SMRT over expression on the Cyp1a1 mRNA levels in murine hepatoma Hepa 1c1c7 cell line. Hepa 1c1c7 cells were maintained in Dulbecco's modified Eagle's medium (DMEM), and competent cells were successfully produced using calcium chloride method. Cells were transformed using plasmid DNA and Lipofectamine. TCDD was employed as an inducing agent for CYP1A1. Total cellular RNA was isolated and real-time PCR of Cyp1a1 was conducted. Statistical analysis was conducted using one-way analysis of variance (ANOVA) followed by Student–Newman–Keul’s test. Our results showed that, cells transfected with the co-repressor SMRT has lower TCDD-mediated induction of Cyp1a1 mRNA without affecting constitutive Cyp1a1 mRNA levels, i.e., SMRT was able to significantly decrease inducible Cyp1a1 mRNA levels in Hepa 1c1c7 cells. Moreover, our work demonstrated that calcium chloride is a convenient method for routine transformation. Our work will open new avenues for treatment of carcinogenesis involving CYP1A1 inducing carcinogens.

The second stage, in which the star uses nuclear fuel in its interior, represents the helium burning phase. At that stage, three elements are synthesised: carbon, oxygen, and neon. This paper aims to establish a numerical solution for the helium burning system (HBN) fractal-fractional differential equations (FFDEs). The extended operative matrix method (OM) is employed in the solution of a system of differential equations. The product abundances of the four elements (helium, carbon, oxygen and neon) were obtained in a form of divergent series. These divergent series are then accelerated using Euler-Abell transformation (EUAT) and Pade approximation (EUAT-PA) to obtain more reliable results. Nine fractal-fractional (FF) gas models are calculated, and fractal-fractional parameters’ influence on product abundances is discussed. The findings show that modeling nuclear burning networks with the OM fractal-fractional derivative produces excellent results, establishing it as an accurate, resilient, and trustworthy approach, and the fractional HB models can have a considerable impact on stellar model calculations.

Purpose: This study was conducted to determine the impact of supervisory behaviour on organisational commitment in Libyan Government Institutions through the mediation role of organisational justice. The population of the study is managers and employees in the capital of Tripoli and the western part of Libya. The sample size was 302, selected randomly. This study used oriented supervisory behaviour, supportive supervisory behaviour, participatory supervisory behaviour, and supervision behaviour directed at achievement as independent variables. The mediating variable is organisational justice, and the dependent variable is organisational commitment.

Results: The result confirmed a significant impact of the independent variables on organisational commitment. For the mediation effect, organisational justice mediates the relationship between supervisory behaviour, participatory supervisory behaviour, supervisory behaviour, and organisational commitment. In contrast, no significant mediation was found between supervision behaviour directed at achievement and organisational commitment.

Background

Spinal anesthesia (SA) remains the most popular anesthetic technique for caesarean sections (CS), as it abolishes the possible risks of pregnant airway management. The ability to anticipate the episodes of hypotension following spinal anesthesia will enable anesthesiologists to interfere early and provide better patient management.

Objective

The aim of the current study was toevaluate the perfusion index and the blood pressure positional changes in the prediction of hypotension after SA in CSs.

Patients and methods

A prospective cohort study was conducted at the Obstetrics and Gynecology Department of Zagazig University Hospitals. A total of 80 pregnant women who were prepared for elective CS delivery, aged from 18 to 40 years with ASA-II (American Society of Anesthesiologists Status), were recruited in the current study.

Results

The mean perfusion index (PI) pre-spinal was 5.81 and immediately after spinal was 4.65 with a statistically significant decrease (P<0.001). There was also a statistical difference between the mean of mean arterial pressure (MAP) of the studied cases pre-spinal at the lateral position (91.76 mmHg) and mean MAP in the supine position (83.29 mmHg) with P-value <0.001, with a mean difference of 8.48 mmHg. PI cut-off >4 had a sensitivity of 85.9%, specificity of 75%, and accuracy of 83.8% in the prediction of hypotension. The positional change in blood pressure at cut-/off >5 mmHg had a sensitivity of 82.8%, specificity of 75%, and accuracy of 81.3% in the prediction of hypotension among cases.

Conclusion

The preoperative PI and positional blood pressure change can predict spinal anesthesia 

The present study was conducted at the Poultry Research Center, Faculty of Agriculture; Sebha University, Libya. The feeding trial lasted 42 days in total. A local hatchery provided 240 unsexed one-day-old broiler chicks (Ross 308). The birds were randomly distributed into four groups, and each group was then divided into four replicates, with 15 birds in each group. The objective of the current study was to examine the impact of ginger powder as a natural feed supplement on broiler chickens' growth performance, hematological parameters, and serum lipids. Four dietary treatments were formulated and supplemented with ginger powder at levels 0%, 0.2%, 0.4% and 0.6%. The findings exhibited substantial differences in body weight and weight gain across the experimental groups. Birds fed ginger-enriched diets had higher feed conversion and lower feed intake than control birds (P<0.05). Birds fed a 0.6% ginger powder diet compared to the control group had considerably superior productive performance (P<0.05), while feed consumption was lowered. Dietary ginger powder supplementation improved hematological parameters; white blood cells, lymphocytes, heterophils, and the lymphocyte to heterophil ratio were improved with dietary ginger powder supplementation (P<0.05). Additionally, as compared to the control group, ginger powder groups significantly (P<0.05) lowered serum triglycerides, total cholesterol, and very low-density lipoprotein. While supplementation of dietary ginger powder significantly increased (P<0.05), the levels of high-density lipoprotein against the control group. In conclusion, ginger supplementation had a positive …