The global expansion of mobile communication technologies has increased exposure to 

radiofrequency electromagnetic fields (RF‑EMF). Although RF radiation is categorized as 

non‑ionizing, growing experimental evidence suggests that prolonged exposure may influence 

biological systems through oxidative stress mechanisms (Dasdag & Akdag, 2016; Yakymenko 

et al., 2016). This study presents a literature‑based experimental model evaluating potential 

hematological and oxidative responses to chronic RF‑EMF exposure. Modeled data were 

derived from previously published experimental investigations examining mobile phone 

radiation in the 900–1800 MHz frequency range (Wang & Zhang, 2017; Kıvrak et al., 2017). 

Simulated exposure conditions included 6 hours of daily radiation for 60 consecutive days. 

Modeled results indicate reductions in erythrocyte indices and increased leukocyte counts, 

accompanied by elevated lipid peroxidation marker malondialdehyde (MDA) and decreased 

antioxidant enzymes superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). 

These patterns are consistent with mechanisms previously reported in experimental RF‑EMF 

studies (Zothansiama et al., 2017; Henschenmacher et al., 2022) and support oxidative 

imbalance as a central pathway underlying biological interaction with radiofrequency 

radiation.