منى أحمد علي الطاس
عضو هيئه تدريس
عضو هيئة تدريس قار
المؤهل العلمي: ماجستير
الدرجة العلمية: مساعد محاضر
التخصص: فسيولوجي حيوان - أحياء...علم حيوان
قسم الاحياء / علم الحيوان - كلية الآداب و العلوم - بدر
حول منى
I am Mona Ahmed Ali Attas. Date of Birth: 1 September 1986 Place of Birth: Badr I studied at the Faculty of Arts and Sciences, Badr, in the Department of General Biology. I graduated in 2009 from the Faculty of Arts and Sciences, Badr, with an excellent grade. I ranked first among the Faculties of Science at Al-Jabal Al-Gharbi University and was awarded a top-graduate scholarship (Decision No. 502). I pursued my postgraduate studies at the Faculty of Science, Alexandria University, where I obtained a Master’s degree in Zoology. My thesis was entitled: “Role of Ginkgo biloba Extract against Rotenone-Induced Neurotoxicity.” I was awarded the Master’s degree with an excellent grade and honors in 2017. During the academic year 2018–2019, I collaborated with the Faculty of Arts and Sciences, Badr, in the Department of Zoology. I was officially appointed to the faculty on 2 December 2019 by a decision issued by the University of Zintan, and I became a faculty member at the college. I prepared a research paper entitled: “Oral Supplements of Ginkgo biloba Extract Alleviate Neuroinflammation, Oxidative Impairments and Neurotoxicity in Rotenone-Induced Parkinsonian Rats.” The paper was published in December 2020 in a Scopus-indexed journal. I am currently engaged in conducting valuable ongoing research, alongside my experience in teaching as a faculty member at the college.
المنشورات العلمية
Oral Supplements of Ginkgo biloba Extract Alleviate Neuroinflammation, Oxidative Impairments and Neurotoxicity in Rotenone-Induced Parkinsonian Rats
Journal ArticleBackground: Ginkgo biloba extract (GbE) is known to contain several bioactive compounds and exhibits free radical scavenging activity. Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and is associated with oxidative stress, neuroinflammation and apoptosis.
Objective: The current study aimed to investigate the neuroprotective effect of GbE in a rat model of PD induced by rotenone (ROT; a neurotoxin).
Methods: Twenty-four male albino rats were randomly divided into four groups of six rats each: normal control, GbE treated, toxin control (ROT treated) and GbE+ROT group.
Results: Oral administration of ROT (2.5 mg/kg b.w.) for 50 days caused an increased generation of lipid peroxidation products and significant depletion of reduced glutathione, total thiol content and activities of enzymatic antioxidants, i.e., superoxide dismutase and glutathione peroxidase in the brains of treated rats. Furthermore, ROT caused an elevation in acetylcholinesterase, interleukin-1β, interleukin- 6 and tumor necrosis factor-α and a significant reduction in dopamine in the stratum and substantia nigra. Immunohistochemical results illustrated that ROT treatment reduced the expression of tyrosine hydroxylase (TH). GbE treatment (150 mg/kg b.w./day) significantly reduced the elevated oxidative stress markers and proinflammatory cytokines and restored the reduced antioxidant enzyme activities, DA level and TH expression. These results were confirmed by histological observations that clearly indicated a neuroprotective effect of GbE against ROT-induced PD.
Conclusion: GbE mitigated ROT-induced PD via the inhibition of free-radical production, scavenging of ROS, and antioxidant enhancement.
Keywords: Ginkgo biloba; Parkinson's disease; ROT treatment; neuroprotection; oxidative stress; rotenone.
AHMMED MONA TASS ALI, (12-2020), Current Pharmaceutical Biotechnology: Bentham science buplisher, 12